Substance AdditionProposedProposed RegulationSubstance Addition
SB3221 introduced to add xylazine as a Schedule III controlled substance and reorganize controlled substance schedules (effective date proposed)
Illinois Controlled Substances Act (720 ILCS 570)Illinois General AssemblyIllinois, US
Announced
Feb 2, 2026
Implementation
Jan 1, 2027
Description
Illinois SB3221 (104th GA) proposes amendments to the Illinois Controlled Substances Act to make structural/organizational changes to controlled substance schedules and to add xylazine as a Schedule III controlled substance, with specified exceptions per the bill synopsis. The bill status/synopsis indicates a proposed effective date of January 1, 2027. Compliance relevance: if enacted, xylazine scheduling would trigger controlled substance handling, security, and compliance screening requirements for impacted entities (including veterinary-related stakeholders depending on exemptions).