Illinois SB3221 introduced to add xylazine as a Schedule/Class III controlled substance with proposed effective date Jan 1, 2027

SB3221 (104th GA) proposes amending the Illinois Controlled Substances Act to add xylazine as a Schedule/Class III controlled substance and make related structural/list changes, with stated exemptions for specified veterinary/animal-drug contexts (per research text summary). The bill status page shows the bill was referred to Senate Assignments on 2026-02-02 and includes a proposed effective date of 2027-01-01. If enacted, entities handling xylazine in non-exempt contexts would face new controlled-substance compliance obligations (storage, handling, distribution controls) and potential criminal liability exposure; organizations with veterinary or animal-health operations should review how exemptions would apply to their use cases.