CDC/NIOSH published a Federal Register notice opening a docketed public comment process (CDC-2024-0085; NIOSH-153-F) for five draft NIOSH Skin Notation Profiles: allyl alcohol (CAS 107-18-6), formamide (CAS 75-12-7), formic acid (CAS 64-18-6), phenothiazine (CAS 92-84-2), and picric acid (CAS 88-89-1). For compliance and EHS teams, this signals potential forthcoming updates to NIOSH skin notation determinations used in occupational hazard communication and exposure control programs. The notice also highlights a methodological/documentation change in the draft profiles (removal of skin-to-inhalation dose (SI) ratio content from individual profile documents based on reviewer feedback) and explicitly requests stakeholder input on whether SI ratio information should be removed or included going forward.