OEHHA released a draft document for public review that summarizes the carcinogenicity data and derives a cancer inhalation unit risk factor (IUR) for acrolein under Proposition 65. The IUR is a quantitative value used to calculate cancer risk from inhalation exposure, which helps businesses determine whether Proposition 65 warnings are required for products or activities involving acrolein exposures.
OEHHA added N-methyl-N-formylhydrazine to the Proposition 65 list as a carcinogen effective December 8, 2025. The listing was done via the 'State's Qualified Experts' mechanism based on the Carcinogen Identification Committee's determination that this chemical was clearly shown to cause cancer. Businesses have a one-year grace period until December 8, 2026 to provide warnings for significant exposures.
OEHHA added the developmental toxicity endpoint to the existing Proposition 65 listing for bisphenol S (BPS) effective December 8, 2025. This expands the reproductive toxicity listing which already included female reproductive toxicity (listed December 29, 2023) and male reproductive toxicity (listed January 3, 2025). Warning requirements for the developmental toxicity endpoint are effective December 8, 2026.
OEHHA issued an information letter regarding Proposition 65 warning requirements for items such as receipts and shipping labels that may contain bisphenol S (BPS). The letter provides guidance on warning obligations following the listing of BPS for reproductive toxicity endpoints.
OEHHA proposed amendments to Title 27, California Code of Regulations, Section 25705(b) to adopt No Significant Risk Levels (NSRLs) for 1-bromopropane (54 micrograms per day) and diethanolamine for dermal exposure (6.4 micrograms per day). The diethanolamine NSRL applies only to dermal routes of exposure. The public comment period was extended to November 7, 2025 at the request of industry stakeholders.
OEHHA has added Bisphenol S (BPS) to the Proposition 65 list for reproductive toxicity (male and female endpoints). Products containing BPS that may cause significant exposures require Proposition 65 warnings when sold in California. BPS is commonly used as a BPA replacement in thermal paper, plastics, and other consumer products.