EPA final rule updates TSCA New Chemicals regulations (PFAS ineligible for LVE/LoREX; approvals required before manufacture)

EPA finalized updates to TSCA New Chemicals Program regulations (40 CFR parts 720, 721, 723, 725). Key compliance impacts include making PFAS categorically ineligible for Low Volume Exemptions (LVE) and Low Release and Exposure Exemptions (LoREX), and requiring EPA approval of LVE/LoREX before manufacture can commence, along with broader procedural updates aligning with Lautenberg amendments. Companies submitting PMNs/SNUNs/MCANs or relying on exemptions should update internal review timelines, exemption eligibility screening (including PFAS determination), and submission completeness processes.