EPA final rule updates TSCA New Chemicals Regulations (40 CFR Parts 720, 721, 723, 725)

EPA finalized amendments to the TSCA New Chemicals Program regulations (including 40 CFR parts 720, 721, 723, and 725). The update includes substantive procedural and eligibility changes affecting PMNs/SNUNs and exemptions—highlighted in the research as making new PFAS categorically ineligible for Low Volume Exemptions (LVE) and Low Release and Exposure Exemptions (LoREX), and requiring EPA approval of LVE/LoREX notices prior to commencing manufacture. Compliance teams should review internal new-chemical submission workflows, exemption screening logic (including PFAS), and timing assumptions for starting manufacture/import after submissions.