EPA publishes final SNUR batch “24-4.5e” (effective Jan. 5, 2026) and logs multiple proposed SNUR batches/amendments with comment deadlines

EPA’s New Chemicals Program updates reflect multiple Significant New Use Rule (SNUR) actions under TSCA Section 5 affecting substances that were subject to PMNs/TSCA orders. EPA published a final SNUR batch (“24-4.5e”) in the Federal Register on Nov. 4, 2025, with an effective date of Jan. 5, 2026, creating Significant New Use Notice (SNUN) notification triggers for the covered substances/uses. EPA also published several proposed SNUR batches (Nov. 3, 2025) and proposed amendments to existing SNURs (Oct. 28, 2025), each with associated public comment periods via Regulations.gov dockets. Compliance teams should review whether any substances in their portfolios are covered by the final SNUR effective Jan. 5, 2026 and monitor/participate in proposed SNUR actions that could add or modify SNUN obligations.