EPA released its latest biannual update to the TSCA Chemical Substance Inventory, which contains all existing chemical substances manufactured, processed, or imported in the U.S. under TSCA that do not qualify for an exemption or exclusion. The non-confidential portion of the Inventory is publicly available on EPA's website. This regular update ensures timeliness and accuracy of chemical substance information for regulatory compliance purposes.
EPA announced availability of the latest update to the public (non-confidential) TSCA Inventory as part of its biannual posting cycle, including updates to inventory totals and associated data elements (e.g., commercial activity, unique identifier data, regulatory flags). EPA also notes the next regular update is planned for winter 2026. Compliance teams should refresh internal inventory reference datasets and re-check substance listing status and applicable flags used to support TSCA Inventory determinations.
EPA announced availability of the latest biannual update to the public (non-confidential) portion of the TSCA Inventory, including updates to commercial activity status and regulatory flags (e.g., SNUR and test order indicators). Compliance teams that screen products or raw materials against the TSCA Inventory should refresh internal reference datasets and verify substance status and regulatory flags against the latest posting.
EPA announced significant process improvements to accelerate Low Volume Exemption (LVE) reviews under TSCA. The agency completed risk assessments for 106 LVEs in just two months and increased the average number of LVE risk assessments from 15 per month to 53 per month, representing an increase of over 250%. This operational change reduces backlogs and accelerates time-to-market for new chemicals qualifying for LVE status while maintaining safety reviews.
EPA has revised the guidelines for making corrections to the TSCA Chemical Substance Inventory. The updated guidelines provide procedures for manufacturers and importers to correct errors or update information in their Inventory submissions, ensuring accurate chemical substance records.
EPA opened a 30-day public comment period on its 2024 final risk management rule for perchloroethylene (PCE) under TSCA. This is the first step in EPA's efforts to reconsider and, if appropriate, revise the final risk management rule. The review is being done in accordance with applicable law, Executive Orders, and Administration policies, including Executive Order 14219 on ensuring lawful governance.
EPA released new resources to assist companies submitting new chemical notices (PMNs) under TSCA. The resources are designed to improve submission quality and efficiency in the premanufacture notification process, helping companies comply with TSCA Section 5 requirements.
EPA withdrew the proposed Significant New Use Rules (SNURs) under TSCA for 18 chemical substances that were proposed on June 20, 2023. EPA withdrew the proposed rules because the Agency withdrew the TSCA Order that was the basis of the rules on December 18, 2024. The original proposed rules were published at 88 FR 39804 on June 20, 2023.
EPA withdrew the previously proposed Significant New Use Rules (SNURs) for 18 chemical substances (SNUR batch 23-2.5e). EPA stated the withdrawal was due to the withdrawal of the underlying TSCA section 5(e) order that formed the basis for the proposed SNURs. For compliance teams tracking these proposed SNUR notification obligations, the withdrawal means the proposed significant new use notification requirements will not proceed as proposed, unless EPA initiates a new action in the future.
EPA withdrew the proposed significant new use rules (SNURs) for 18 chemical substances that were published on June 20, 2023 (Batch 23-2.5e). The withdrawal was necessary because EPA had withdrawn the underlying TSCA Order on December 18, 2024, which was the basis for the proposed SNURs. The SNURs would have required notification to EPA before commencing certain activities with these chemicals.
EPA issued additional test orders to support risk evaluations of eight chemicals under TSCA. The test orders require manufacturers to conduct testing and submit data that will inform EPA's risk evaluation process for these chemicals under TSCA Section 4.
EPA issued an interim final rule that delays the TSCA §8(a)(7) one-time PFAS reporting submission period. The submission window start moved from July 11, 2025 to April 13, 2026. EPA states most reporters must submit by Oct. 13, 2026, while small manufacturers reporting exclusively as PFAS article importers have until Apr. 13, 2027. Compliance teams should adjust internal data-collection and supplier engagement timelines for the 2011–2022 PFAS manufacture/import lookback accordingly.
EPA’s TSCA §8(a)(7) PFAS reporting program page describes the current reporting window and extended submission deadlines established via an interim final rule. Per the research text, submissions are due by Oct 13, 2026 for most manufacturers (including importers), and by Apr 13, 2027 for small manufacturers that only need to report PFAS in imported articles. Companies in scope should align data collection and internal reporting systems to the updated reporting window and submission deadlines and monitor ongoing rulemaking that could further alter scope.
The U.S. Government Accountability Office (GAO) issued a report (GAO-25-106839) finding that EPA's TSCA New Chemicals Program does not follow key management practices. Chemical manufacturers raised concerns about unclear requirements and review delays. GAO found EPA lacks a systematic process to manage and assess program performance, which may impede effective implementation. Companies submitting new chemical notifications should be aware of ongoing program challenges and potential process changes.
EPA released its 2025 Annual Plan for Chemical Risk Evaluations under TSCA, providing transparency on upcoming regulatory activities. The plan confirms completion of final risk evaluations for DIDP and DINP by December 31, 2024, and documents the designation of five chemical substances as High-Priority for risk evaluation. Compliance teams should use this planning document to anticipate upcoming risk management actions and regulatory timelines for chemicals in their supply chains.
EPA announced availability of the latest update to the non-confidential TSCA Chemical Substance Inventory (Update #7). Inventory updates support determinations of whether a substance is listed as an existing chemical and provide updated activity status and regulatory flags used for compliance screening. Companies should refresh internal Inventory datasets and screening tools used for TSCA Section 5 and import/manufacture compliance checks.
EPA announced availability of and seeks public comment on the draft scope of the TSCA risk evaluation for vinyl chloride (CASRN 75-01-4). The scope document must include conditions of use, hazards, exposures, and potentially exposed or susceptible subpopulations that EPA expects to consider in the risk evaluation. This is part of EPA's High-Priority Substance review process under TSCA.
EPA submitted an information collection request to the Office of Management and Budget (OMB) for renewal of TSCA Section 8(b) reporting requirements for TSCA Inventory Notifications. This renewal continues the existing reporting framework for chemical manufacturers and processors to notify EPA of chemical substances on the TSCA Inventory. The notice requests public comments on the renewal.
EPA finalized amendments to the TSCA new chemicals regulations governing EPA’s review of Premanufacture Notices (PMNs) and Significant New Use Notices (SNUNs). The research summary highlights changes that (a) make PFAS and other PBT chemicals ineligible for certain exemptions (e.g., Low Volume Exemption (LVE) / LoREX) and (b) require EPA to make one of the statutory determinations before manufacture/processing may begin. Compliance teams should review impacts on new chemical submissions, exemption strategies, and any PFAS/PBT-related R&D/manufacturing plans, and update internal submission workflows accordingly.
EPA finalized amendments to the TSCA New Chemicals Regulations (40 CFR Parts 720, 721, 723, and 725). As highlighted by EPA, the changes remove eligibility for certain exemptions (e.g., LVE/LoREX) for PFAS and other PBT chemicals and require EPA to make one of the five statutory determinations for PMNs/SNUNs/MCANs before manufacture/processing begins. Compliance teams submitting PMNs/SNUNs or relying on exemptions should reassess exemption strategies, timelines, and documentation in light of the updated rules.